Welcome to My Site

If this is your first visit, welcome! This site is devoted to my life experiences as a Filipino-American who immigrated from the Philippines to the United States in 1960. I came to the US as a graduate student when I was 26 years old. I am now in my early-80's and thanks God for his blessings, I have four successful and professional children and six grandchildren here in the US. My wife and I had been enjoying the snow bird lifestyle between US and Philippines after my retirement from USFDA in 2002. Please do not forget to read the latest national and International News in this site . I have also posted some of my favorite Filipino and American dishes and recipes in this site. Some of the photos and videos in this site, I do not own. However, I have no intention on infringing on your copyrights. Cheers!

Tuesday, May 24, 2016

New Drug for the Treatment of Parkinson's Psychosis


As a former FDA employee in the Center of New Drugs and a primary caretaker for a love one with Parkinson, the above news attracted my attention. The new drug is Nuplazid or Pimavanserin manufactured by Acadia Pharmaceuticals, Inc.

Pimavanserin was approved by the FDA just recently specifically for the treatment of Parkinson's disease psychosis.
It works in a different way than other antipsychotics: it does not block dopamine. It is a selective serotonin inverse agonist, meaning it targets serotonin receptors. This makes it a safer choice when treating people with PD that are experiencing psychoses, because it can reduce hallucinations without affecting motor performance.

NUPLAZID™ (pimavanserin) is the first and only medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis.

According to the National Parkinson Foundation, about one million people in the United States and from four to six million people worldwide suffer from Parkinson’s disease. An estimated 40 percent of these patients have Parkinson’s disease psychosis, a debilitating condition that is characterized by hallucinations and delusions, is associated with significant caregiver burden, and is a major reason for nursing home placement among Parkinson’s patients.

The following information is from the insert published by Acadia Pharmaceuticals, Inc.:

Important Safety Information and Indication for NUPLAZID™ (pimavanserin) tablets

WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. NUPLAZID is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson’s disease psychosis.

INDICATIONS AND USAGE
NUPLAZID is an atypical antipsychotic indicated for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis.

QT Interval Prolongation: NUPLAZID prolongs the QT interval. The use of NUPLAZID should be avoided in patients with known QT prolongation or in combination with other drugs known to prolong QT interval including Class 1A antiarrhythmics or Class 3 antiarrhythmics, certain antipsychotic medications, and certain antibiotics. NUPLAZID should also be avoided in patients with a history of cardiac arrhythmias, as well as other circumstances that may increase the risk of the occurrence of torsade de pointes and/or sudden death, including symptomatic bradycardia, hypokalemia or hypomagnesemia, and presence of congenital prolongation of the QT interval.

Adverse Reactions: The most common adverse reactions (≥2% for NUPLAZID and greater than placebo) were peripheral edema (7% vs 2%), nausea (7% vs 4%), confusional state (6% vs 3%), hallucination (5% vs 3%), constipation (4% vs 3%), and gait disturbance (2% vs <1%). Drug Interactions: Strong CYP3A4 inhibitors (eg, ketoconazole) increase NUPLAZID concentrations. Reduce the NUPLAZID dose by one-half. Strong CYP3A4 inducers may reduce NUPLAZID exposure, monitor for reduced efficacy. Increase in NUPLAZID dosage may be needed. Renal Impairment: No dosage adjustment for NUPLAZID is needed in patients with mild to moderate renal impairment. Use of NUPLAZID is not recommended in patients with severe renal impairment. Hepatic Impairment: Use of NUPLAZID is not recommended in patients with hepatic impairment. NUPLAZID has not been evaluated in this patient population. Pediatric Use: Safety and efficacy have not been established in pediatric patients. Dosage and Administration: Recommended dose: 34 mg per day, taken orally as two 17 mg tablets once daily, without titration. For details on the balancing act of treatment between motor symptoms and psychosis read the following: http://www.parkinson.org/understanding-parkinsons/non-motor-symptoms/Psychosis/What-are-the-Treatment-Options-for-Psychosis

1 comment:

McAllister Craig said...

How my son was cured from psychosis.
My son Jim was down with psychosis which his major symptoms was his aggressiveness and violence towards us and anyone, the psychosis which struck him at the age of 17 he had to drop out of high school and he was kept under watch indoors and this took the major part of his life because it all lasted for 14 more years before i was able to come across this useful website www.brainhealthpress.com that treats and cures psychosis, schizophrenia and i contacted them, and told them all about my son's condition and they gave me hope and assured me that he will be fine and in the end their doctor came to our house and treated him personally at our house in Texas using their herbal medicine which he was on for 3 months and his condition was better and in 6 months he had no symptoms of psychosis anymore, he was normal again and he was no longer aggressive and violent. Today i am a proud father, because i was shy about him before where others introduced their son and i remember mine. Before this we had tried various prescriptions (rispedal, zyprexa) from our psychiatrist and several therapies to suppress the symptoms that all failed. When he was 25 his condition heightened and he became super aggressive and very violent. Today my son is doing fine and he is no longer aggressive to anyone. If you or anyone you know have psychosis, bipolar disorder or schizophrenia simply contact them on (info@brainhealthpress.com) they can help you regain your lost sanity just like my son. I hope this information helps someone out there.

Related Posts Plugin for WordPress, Blogger...